HLA, immunogenetics, pharmacogenetics and personalized medicine

pharmacogenetics and personalized medicine in pancreatic cancer

pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...

Pharmacogenetics/genomics and personalized medicine.

Despite the marked advances in drug therapy, some patients do not respond favorably or suffer severe adverse drug effects. Pharmacogenetic studies have shown that polymorphisms of drug metabolizing enzymes, transporters and receptors contribute to variable drug response. Owing to the complexity of drug actions, a broader genomics approach aims at finding new drug targets and optimizing therapy ...

Pharmacogenetics, Personalized Medicine, and Race

Metabolic pathways — the chains of chemical reactions that occur in each cell in the body — are affected by a wide range of DNA mutations, including single nucleotide polymorphisms (SNPs); gene deletions, duplications, and insertions; mutations in the regulatory elements of genes; and variations in gene copy number. The identification of gene variants (alleles) that influence drug metabolism is...

Pharmacogenetics and Pharmacogenomics of Colorectal Cancer: Moving Towards Personalized Medicine

Pharmacogenetics, Pharmacogenomics and Ayurgenomics for Personalized Medicine: A Paradigm Shift

The value of health care can be increased tremendously through individualized medicine. With the promise of individualized medicine, healthcare professionals will be able to better predict disease risk, prevent development of disease and manage treatments more efficiently thereby allowing people to be healthier and active longer. The developments in the area of pharmacogenetics/pharmacogenomics...